Federal cell says tight controls on painkiller Vicodin

In a move to stem the epidemic of prescription drug deaths, a federal advisory panel has proposed tighter controls on the narcotic painkiller finest acknowledged through the brand title Vicodin. It is actually the nation's most extensively prescribed drug.

By a 19-to-10 vote, an advisory panel for the U.S. Foods and Drug Administration suggested Friday the agency reclassify hydrocodone, the energetic ingredient in Vicodin, as being a Routine II narcotic, putting it from the similar category as other extensively abused medicines, which include OxyContin and fentanyl.

If your FDA approves the alter, individuals might be capable to get fewer hydrocodone capsules at 1 time, and there might be a lot more restrictions on refills. Moreover, pharmacies would really need to comply with stricter procedures for dealing with and storing the drug.

Routine II would be the government's most restrictive category for pharmaceuticals with accepted health care makes use of. Hydrocodone is now listed on Routine III.

The United states of america consumes 99% on the hydrocodone generated around the world, and medical practitioners create additional prescriptions for it than to the primary antibiotic and hypertension drugs.

Prescription medicines ?a mainly narcotic painkillers this kind of as hydrocodone ?a lead to or contribute to a lot more deaths than heroin and cocaine mixed. Consequently, drug fatalities have surpassed deaths from motor car crashes, lengthy the primary reason for accidental death within this nation.

A Los Angeles Occasions evaluation of three,733 prescription drug-related fatalities in Southern California from 2006 by 2011 discovered that hydrocodone was involved with 945 with the deaths, greater than any other prescription medicine.

Medical professionals have prescribed hydrocodone with handful of restrictions because it was introduced 4 decades ago. As a consequence of the perception that it is actually much less risky than other narcotic painkillers, it really is extensively prescribed by common practitioners and dentists.

Nevertheless drug enforcement officials have prolonged complained that hydrocodone was hugely addictive and extensively abused.

For several years, the FDA resisted tightening the guidelines on its use from concern that performing so would make it additional complicated for individuals with reputable discomfort to receive the drug. The U.S. Drug Enforcement Administration asked the agency to reconsider in light of your drug's widespread availability about the black market place.

Earlier this week, the American Academy of Discomfort Medicine sent the FDA advisory panel a letter saying that whilst it had some concern that tighter principles could curtail respectable prescribing, it didn't oppose moving hydrocodone to Routine II.

Morgan Liscinsky, a spokeswoman to the FDA, stated she couldn't say once the agency would act for the recommendation.

In trying to find to stem the maximize in fatal drug overdoses, authorities have focused on how addicts and drug dealers get prescription narcotics illegally, this kind of as by stealing from pharmacies or relatives' medicine cabinets. Current posts from the Occasions, nonetheless, reported that a lot of overdoses stem from medicines prescribed for that deceased by a medical professional.

In virtually half with the prescription drug fatalities in 4 Southern California counties, medicines prescribed by doctors induced or contributed to your death, in accordance with a Instances evaluation of coroners' records.

Seventy-one medical professionals, a small fraction of all practicing doctors within the 4 counties, have been related that has a disproportionate amount of deaths.

In response for the posts, the Health care Board of California has appealed towards the public to report circumstances of extreme prescribing, and legislative leaders, such as the president of your California Senate, have promised to offer the board much more investigators and higher authority to quit reckless prescribing.

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FTC research taking aim at on-line promoting of booze

The Federal Trade Commission (FTC) ideas this summer time to propose techniques the alcoholic beverage field can far better defend underage viewers from seeing its ads on the internet.
Distillers, brewers and wineries pour countless bucks into brand promotion on Twitter, Facebook as well as other social media, and market critics contend these are not performing sufficient to avoid youthful people from getting these messages.

"We're carrying out a deep dive on how they are making use of the net and social media," stated Janet Evans, a attorney using the FTC, that's conducting a year-long review thanks to be released by early summer season. "We're concentrating on underage exposure."

She wouldn't elaborate on any possible suggestions that may come from the research, which started in April 2012.

The FTC is reviewing information from 14 major producers, Evans stated, which includes Beam Inc, the maker of Jim Beam, Diageo Plc, household to Johnnie Walker, and Constellation Brand names Inc, which helps make Robert Mondavi and Ravenswood wines.

The FTC report "is anything we get critically and spot at large priority," explained Karena Breslin, director for digital advertising at Constellation.

The FTC has manufactured two requests for info given that the review started, she mentioned.

The regulatory agency hasn't mentioned it intends to impose restrictions on liquor organization social media promoting nevertheless it could make suggestions towards the field.

The FTC is empowered to file suit to guarantee shoppers are protected from deceptive promoting practices, Evans stated, but she stressed that research of this nature are meant to encourage far better self-regulation, not supply a basis for the situation.

Market executives say alcohol makers and distributors voluntarily adhere for the similar industry-set typical for advertising and marketing to underage viewers on social media web-sites the sector set for its adverts on Television together with other media. That calls for that at the least 71.six % of an audience includes adults 21 and older.

"No one particular inside their proper thoughts would desire to promote to folks who cannot legally obtain their item," stated Frank Coleman, senior vice president for Distilled Spirits Council in the United states of america (DISCUS), the trade group that sets the industry's promoting codes.

Coleman also cited latest information displaying the audiences for Facebook and Twitter are skewed heavily in the direction of viewers that are over the legal drinking age.

"According to Nielsen's newest information, the demographic audience for Facebook is 83.five % 21 many years and older, and for Twitter it truly is 85 %," Coleman stated.

In June 2011, DISCUS revised its code upwards to 71.six % from 70 %, immediately after the FTC advised it critique the normal to much better reflect U.S. Census population information.

Sector critics, together with David Jernigen, director of your Center on Alcohol Marketing and advertising and Youth at Johns Hopkins University, and Sarah Mart, exploration director on the advocacy group Alcohol Justice, contend the field did not go far sufficient and need to increase the conventional even more.

Jernigen explained it must be no less than 85 % to properly secure youth, so there can be no over 15 % exposure on the underage drinking population.

"The marketplace says its self-regulating but it is ineffective and social media opens up a entire new set of challenges for the reason that their advertisements are all over the place," stated Mart.

Coleman stated the group now demands members to set up age-checking equipment by means of immediate messaging being a gateway to Twitter feeds together with other branded Net platforms that request the consumer for the birth date prior to admitting them.

From the initial 9 months of 2012, beer, wine and spirits companies spent an estimated $35 million for paid Net show promoting, but field executives estimate several millions extra had been spent on internet site creation, video manufacturing for platforms like Google's YouTube and social media advertising efforts.

"We've drastically adjusted far more cash to digital for on the net video, web-sites, Facebook and Twitter information," mentioned Kevin George, worldwide chief marketing and advertising officer for Jim Beam, which spends 30 % of its media devote for on the net outlets, up from ten % in 2008, he stated.

Numerous businesses are expanding their digital employees. Wine maker Constellation employed Breslin 3 many years ago to initiate digital advertising and now features a crew of 5 reporting to her.
Several alcoholic beverage providers flocked to Facebook due to the fact it demands consumers to publish their birth dates when signing up.

Final year Twitter partnered with Buddy Media to supply a screening instrument that sends a direct message to followers who click on an alcoholic brand. The message sends the fan a hyperlink to a web page that asks for date of birth.

Salesforce.com purchased Buddy Media final June, which can be now folding the platform into its advertising and marketing cloud portfolio.

Well being advocates and marketplace critics are crying foul. "Facebook together with other interactive platforms are poorly monitored rather than effectively age-protected," mentioned Jernigen of Johns Hopkins University. "Anyone can say they are 21 and click yes."

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Bolshoi Dancing artistic director Sergei Filin assaulted with acid solution within Moscow

MOSCOW - Snow was falling from the late-night darkness Thursday whenever a masked figure named out the title of your most influential guy on the Bolshoi Ballet - and threw acid in his encounter. The victim, Sergei Filin, was badly burned, and his sight is threatened.

Evil and betrayal have prolonged played out within the Bolshoi stage, for the enchantment of ballet lovers. By quite a few accounts Friday, they've spilled more than to the dancers' lives and now jeopardize its leadership. While the motive stays unclear, the assault in central Moscow place a sudden spotlight on festering scandals, battles more than artistic vision and historic struggles to shake off the Bolshoi's Soviet previous.

Filin, an acclaimed dancer, ascended two many years ago on the all-powerful place of artistic director with the renowned Russian ballet business. In that function, his selections can propel dancers to stardom or condemn them to oblivion. The institution he oversees is deemed a nationwide treasure through the guys behind the Kremlin walls, just 500 yards away.

Police and colleagues outlined the bare details in the crime: Filin, a youthful-looking 42-year-old, was attacked about 11:30 p.m. Thursday as he approached his apartment block, on his return from a theatrical celebration with all the city's glitterati. He suffered third-degree burns and underwent eye surgical procedure Friday, in accordance with Anatoly Iksanov, the Bolshoi's director. Police mentioned they had been seeking a motive linked to Filin's operate, but advised the Interfax news agency they didn't rule out a dispute above income or house.

Speculation about who was behind the assault - and why - electrified the dance globe, the place the Bolshoi is acknowledged for that technical brilliance, dramatic characterization and large emotion of its performances - and artistic rivalries - instead of for risky intrigue.

"In the previous they dueled," mentioned Anastasia Volochkova, a former Bolshoi ballerina, on Ekho Moskvy radio. "People made use of to cross swords or attempted to possess it out within a good way. But splashing acid in to the encounter. .?.?. That is so very low. It truly is difficult to make any comment.

"What's taking place there may be a wild and scary battle," she explained. "It's a battle for roles."

Volochkova became regarded right here because the unwanted fat ballerina right after a prior artistic director in the Bolshoi dismissed her in 2003, accusing her of staying as well heavy to lift. She weighed 109 pounds with the time, she mentioned.

Filin had been repeatedly threatened in latest days, in accordance with Katerina Novikova, press secretary to the Bolshoi. His tires had been slashed various instances, his Facebook web page was hacked and he had obtained ominous phone calls, she explained.

On Russian tv, Iksanov advised the assault have to be connected to Filin's operate. Possibly an individual desired to set unique elements in the firm at odds, he explained.

People today who know the organization nicely unleashed their fury above the assault. It had been no accident, mentioned Alexei Ratmansky, who preceded Filin in his Bolshoi publish from 2004 to 2008 and now is artist in residence in the American Ballet Theatre. Within a Facebook posting, he described how the two-centuries-old Bolshoi was getting destroyed by a lack of ethics.

"It's a loathsome cesspool of individuals befriending actors, speculators and scalpers, half-crazy followers, prepared to bite the throats of their idols' rivals, cynical hackers, lies inside the press and scandalous interviews of personnel," he wrote.

The turmoil that seems to possess engulfed Filin started that has a dancer and choreographer who took management on the Bolshoi in 1964 and ran it with an unshakable hand for 30 many years. Yuri Grigorovich was stated to contemplate communism a larger calling than art, and celebration bosses had been pleased on the cost in the muse. The business was a privileged location to get the job done, in which the favored received excellent apartments and possibilities to tour abroad. However the final many years of your Soviet Union brought turbulence, as some dancers agitated for much more daring ballets and approach, whilst other individuals held speedy for the old designs.

In 1995, amid reports the Bolshoi was self-destructing, President Boris Yeltsin intervened, appointing Vladimir Vasiliev as artistic director. Vasiliev, a dashing former dancer, promised he would finish the days when roles have been won by favoritism or political pull rather then brilliance. He even promised to bring in do the job from your West.

4 many years later on, he was out. The Bolshoi was losing stars and luster, and rumors of bitter disagreements swirled. Vasiliev was fired by President Vladimir Putin, reportedly so abruptly that he heard about this within the radio. Putin place the Bolshoi beneath the manage on the Ministry of Culture, and Iksanov was brought in to kind it out.

Yeltsin's appointment of Vasiliev had enraged Grigorovich, who left inside a huff. But his admirers remained, in conjunction with rifts which have hardly ever fairly healed.

Filin started dancing along with the corporation being a younger guy, and two many years ago, returned in the Stanislavsky and Nemirovich-Danchenko Moscow Music Theater, in which he had been artistic director because 2008.

Critics, such as The Washington Post's, liked what they saw. When Filin brought "Coppelia" to Washington final yr, the efficiency received a beautiful evaluation.

Filin discovered a Bolshoi nevertheless afflicted by controversy. A six-year-long renovation of its historic creating was nearing completion, accompanied by reports of corruption and mismanagement. His instant predecessor's contract had not been renewed. The company's manager, who may possibly have gotten the artistic director occupation, was taken from the operating right after sexually explicit photographs have been posted on the internet.

Later on that yr, two vibrant youthful stars, Natalia Osipova and Ivan Vasiliev, defected to your Mikhailovsky Theater in St. Petersburg, their determination described like a hunt for artistic development.

Filin sought modify, bringing in an acclaimed dancer from your United states of america, David Hallberg. The long term employment of the foreigner was apparently a 1st in contemporary instances.

However the Bolshoi will not remain quiet for extended. Not long ago, a group of detractors sent a letter to Putin urging him to change Filin.

Filin made available an upbeat evaluation of his do the job in an interview inside the January concern of Dance Magazine. He explained he had brought discipline on the corporation, that he had managed to help keep the top with the previous when embracing the long term. He didn't describe himself as loved, but he did not appear to thoughts.

"You know," he informed the magazine, "dancers never ever just like the artistic director. I never know the dancers that are joyful with their artistic director."

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Myspace Getting $100 for you to Concept Chief executive officer Level Zuckerberg

Facebook is not charging for poking, and "liking" a photo continues to be totally free to the social networking web-site.

But currently, sending a private message to anyone can price anyplace from $1 to $100 ¡§C in case you are sending to anyone like Facebook CEO Mark Zuckerberg, that's.

"We are testing some excessive cost factors to discover what will work to filter spam," mentioned a Facebook spokeswoman.

Final month, Facebook introduced "paid messages," a characteristic exactly where customers shell out a $1 charge to get their private message sent to an individual's "strict filtering inbox" as an alternative to an obscure "other" inbox. In advance of the transform, Facebook end users have been permitted to send a private message no cost to somebody they did not know or weren't linked with.

"Several commentators and researchers have mentioned that imposing a monetary expense to the sender may well be one of the most efficient technique to discourage undesirable messages and facilitate delivery of messages which can be pertinent and valuable," Facebook stated inside a Dec. twenty statement.

Facebook informed ABCNews.com the $100 private message provide is surely an experiment not only with Zuckerberg but to these that has a substantial amount of subscribers. Don't forget, subscribers are those who are not your pals but can view the material you share with them since they adhere to you. Facebook calls these subscribers a broader group of close friends.

"This check will give a tiny variety of folks the alternative to pay out to possess a message routed to your 'inbox' in lieu of the 'other' folder of the recipient that they're not linked with," explained Facebook. "If you choose rigid filtering, you may see mainly messages from good friends as part of your inbox."

Considering the fact that reaching one billion consumers final October, the social network giant has become revamping its privacy settings and modifying the appear and truly feel with the Facebook practical experience on the internet and in mobile products.

Facebook is "testing intense selling price factors to get rid of spam" with its new messaging charge, the web site explained. As customers turn out to be a lot more acquainted using the new messaging charge, they will recognize the volume of messages obtained might be restricted to a greatest of one particular every week.

Facebook informed ABCNews.com there is a great deal of filtering occurring leading to obtaining the messages which can be only meant to suit your needs, the consumer. As far because the reaction to Facebook's new "paid messages" characteristic, Facebook presented no comment.

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Apple's Mac pc deliveries fall inside Oughout.Utes. because Computer marketplace decreases

According to IDC's quarterly estimates, Apple shipped approximately two.03 million Macs more than the three-month period ending in December, just three,000 units shy of final year's overall performance. Regardless of displaying damaging development in quarter 4, Apple managed to achieve marketplace share above other Computer vendors like Toshiba, which took massive hits in excess of exactly the same period.

It may be speculated that rollout problems together with the newly redesigned iMac are to blame for Apple's slip in to the red, using the all-in-ones even now in brief provide in excess of a month immediately after becoming launched on the finish of November.

General, U.S. Computer shipments fell to 17.75 million from 18.six million a year ago, representing a unfavorable development price of four.five %.

"Although the third quarter was focused for the clearing of Windows seven inventory, preliminary study signifies the clearance didn't drastically improve the uptake of Windows eight methods in Q4," mentioned Jay Chou, senior analysis analyst with IDC's Throughout the world Quarterly Computer Tracker. "Lost during the shuffle to market a touch-centric Computer, vendors haven't forcefully stressed other functions that encourage a much more safe, dependable and effective consumer encounter. As Windows eight matures, as well as other corresponding variables this kind of as Ultrabook pricing carry on to drop, hopefully the Computer market place can see a reset in the two messaging and demand in 2013."

After once more, HP held on to your leading spot, bucking the downward trend to achieve twelve.four % for that quarter on shipments nearing four.eight million units. The organization now accounts for 27 % from the U.S. industry. From the No. two spot was Dell, which suffered a hefty 16.six % year-to-year reduction on somewhat lower than three.five million shipped units, dropping its share from the industry down to 19.six %.

Apple retained its third area ranking effectively behind Dell which has a 11.four % marketplace share for quarter 4, but was ahead of each Lenovo and Toshiba. Apart from HP, Lenovo was the sole significant vendor to demonstrate year-over-year development, gaining 11.six % inside the final quarter of 2012. The firm trailed Apple by some 500,000 shipped units, but rocketed previous Toshiba which suffered an enormous decline, posting 33.9 % detrimental development. To the fourth quarter, Toshiba saw one.26 million PCs shipped, a drop of practically 650,000 units from final year. The company's U.S. industry share fell from ten.two % to seven.one %.

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Just after Two Many years of Gloom, Nokia Has Some Excellent News

Nearly two many years ago, Stephen A. Elop, Nokia's new chief executive, spoke of flaming ocean platforms and shark-infested waters to describe the challenges he inherited because the corporation teetered to the brink of irrelevance.

Mr. Elop painted the bleak outlook as he prescribed a radical remedy to the Finnish cell phone pioneer: The rejection on the company's very own Symbian smartphone operating process for the shotgun wedding to Microsoft, itself stumbling badly with smartphone application. Just after that, income slumped sharply, losses mounted and big layoffs followed.

On Thursday, he delivered sudden great news: a profit. Product sales of its new smartphone line, the Lumia, powered by Microsoft's Windows Cellphone operating technique, soared in excess of 50 % inside the fourth quarter of final year, as outlined by preliminary money facts.

In what was observed as being a make-or-break quarter, Mr. Elop stated Nokia would break even or turn a two % profit as an alternative to report a reduction as substantial as ten %, as analysts anticipated.

Nokia will report its earnings on Jan. 24.

Wall Street reacted on the announcement by sending Nokia's American depositary receipts up 18.67 %, or 70 cents, to $4.45.

"While we absolutely knowledgeable some difficult issues inside the 1st half of 2012, we're managing by way of these concerns," Mr. Elop stated within a conference phone with journalists.

What Nokia has achieved below Mr. Elop will be to generate a line of more and more competitive smartphones which have been beginning to draw favorable comparisons with these from Samsung and Apple, the 2 firms most liable for knocking Nokia from its lofty perch.

"The Lumia smartphones are night-and-day distinct from Nokia's old Symbian handsets," explained Francisco Jeronimo, an analyst using the Worldwide Information Corporation in London. "I assume what we're commencing to view now is what will likely be a steady turnaround in Nokia's fortunes."

The firm, which dominated the cellphone company until eventually Apple introduced its iPhone in 2007, even now includes a prolonged solution to head to accomplish its former stature. Inside the third quarter, Nokia held on to a four % share with the international smartphone market place, and was ranked a distant No. ten during the sector, based on System Analytics, a investigate company.

Samsung and Apple, the No. one and No. two smartphone makers, with each other had 50 % from the international smartphone marketplace, and their product sales have been rising. When its rivals rose, Nokia has created just about five billion euros ($6.five billion) in losses underneath Mr. Elop, and eradicated a third of its do the job force.

The important thing to its turnaround was the introduction in October from the top-of-the-line Lumia 920 and 820, which utilised the new Windows Mobile phone eight operating technique. Considering that then, Nokia has spent heavily on marketing in Britain and Europe to market the designs. The firm is not going to disclose simply how much it had spent on its campaign, but its tv advertisements had been ubiquitous above the holidays, mentioned Neil Mawston, an analyst at Method Analytics in London.

The heavy promotion, which was aided by Microsoft's personal promoting, has assisted the business recapture a number of its lost glory, Mr. Mawston mentioned.

But he warned that "Nokia even now lacks the genuine killer mobile phone which will allow it to compete together with the iPhone five or Samsung Galaxy S III." He anticipated Nokia's share with the worldwide smartphone industry to rise to six % through the finish of your year.

The company's monetary place is probable to revive much more immediately due to the stringent cost-cutting imposed by Mr. Elop, who ran Microsoft's small business program division ahead of joining Nokia in late 2010.

Given that then, Nokia has shut factories across Europe. Final month, the business sold its 540,000-square-foot glass-and-wood headquarters from the Helsinki suburb of Espoo to Finnish investors, and leased it back. The maneuver netted Nokia 170 million euros.

Apart from a a lot more competitive array of phones, Nokia has discarded its market-leader mentality. Workers are now routinely traveling in economic system class and sharing rides to airports. Employees no longer use pricey phone conference calling but talk in group teleconferences employing much less costly World-wide-web calling solutions.

"The firm is usually a great deal more compact now but folks are doing work greater with each other," stated Susan Sheehan, a Nokia spokeswoman. "Everyone has become pitching in."

Even at Nokia Siemens, the company's long-suffering network gear venture, the potential is wanting brighter than it had been two many years ago. On Thursday, Nokia stated the unit, which contributes about 40 % of complete income, would report an operating profit for your quarter, its third consecutive quarterly profit.

Nokia, in its announcement to investors, even revised the operating profit margin forecast on the venture to 13 to 15 % of income, up from a array of four to twelve %.

Wanting ahead, Nokia explained it anticipated to return to an operating reduction of two % of product sales as a consequence of the first-quarter postholiday getting lull and fierce competitors. However the benefits for your coming 3 months could fluctuate broadly.

Pete Cunningham, an analyst at Canalys, a exploration company in Studying, England, explained that Nokia even now faced problems. "2013 could nevertheless turn out to get yet another incredibly tough year for Nokia. It truly is way as well premature to state that the firm has created a turnaround."

Mr. Cunningham mentioned he made use of the Lumia 920, Nokia's newest smartphone, for the duration of the Christmas holidays and liked it.

"But the far more I utilised the telephone, the extra obvious it became to me that you'll find significant gaps among Lumia and its rivals when it comes to the performance and usability of its apps," Mr. Cunningham explained.

"I nonetheless believe you can find a great deal of operate to become accomplished on Lumia."

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